Generation of a human induced pluripotent stem cell line, IMSUTi002-A-1, harboring the leukemia-specific fusion gene ETV6-RUNX1


Reprograming human primary cancer cells remains technically challenging, and leukemia-specific human induced pluripotent stem cell (hiPSC) lines have not yet been generated from tissues of patients with acute leukemia (Muñoz-López et al., 2016). Here, we developed an hiPSC line with a doxycycline-inducible expression system with the fusion gene ETV6-RUNX1 integrated into the genome. This is the most common genetic aberration found in childhood leukemia. This hiPSC line will be a useful model for research on childhood leukemia pathology and risk assessment. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Takahashi M, Yamazaki S
Journal Stem cell research
Publication Date 2019 Oct;40:101546
PubMed 31476588
DOI 10.1016/j.scr.2019.101546

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