Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy
Summary
Our study is the first to reveal that exosomal miR-126-3p, originating from endothelial cells, contributes to ion channel dysfunction by regulating RGS3 signaling in cardiomyocytes. These findings provide new perspectives on the pathogenesis of TTC and suggest potential therapeutic targets for treatment. © 2025. The Author(s).
| Authors | Fan X, Yang G, Wang Y, Shi H, Nitschke K, Sattler K, Abumayyaleh M, Cyganek L, Nuhn P, Worst T, Liao B, Dobreva G, Duerschmied D, Zhou X, El-Battrawy I, Akin I |
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| Journal | Stem cell research & therapy |
| Publication Date | 2025 Feb 4;16(1):36 |
| PubMed | 39901299 |
| PubMed Central | PMC11792229 |
| DOI | 10.1186/s13287-025-04157-0 |