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WTSIi018-B-14

Registration Summary:
WTSIi018-B-14

General

Cell Line
hPSCreg name WTSIi018-B-14
Cite as:
WTSIi018-B-14 (RRID:CVCL_D6KS)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
WTSIi018-B
(HPSI0114i-kolf_2)
WTSIi018-B-21
(Kolf 2.1 J (TARDBP M337V SNV/SNV))
WTSIi018-B-1
(HPSI0114i-kolf_2-C1)
WTSIi018-B-22
(Kolf 2.1 J (TARDBP Q331K WT/SNV))
WTSIi018-B-23
(Kolf 2.1 J (TARDBP Q331K SNV/SNV))
WTSIi018-B-24
(Kolf 2.1 J (FUS R495X WT/SNV))
WTSIi018-B-25
(Kolf 2.1 J (FUS R495X SNV/SNV))
WTSIi018-B-26
(Kolf 2.1 J (FUS R521H WT/SNV))
WTSIi018-B-27
(Kolf 2.1 J (FUS R521H SNV/SNV))
WTSIi018-B-18
(Kolf 2.1 J (TARDBP M337V WT/SNV))
WTSIi018-A
(HPSI0114i-kolf_3)
Last update 18th December 2023
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Provider
Generator Paul-Ehrlich-Institut (PEI)

External Databases
BioSamples SAMEA115039273
Cellosaurus CVCL_D6KS
Wikidata Q127384717

General Information
Publications
* Is the cell line readily obtainable for third parties?
No
Subclone of

Donor Information

General Donor Information
Sex male
Ethnicity White - White British

Phenotype and Disease related information (Donor)
Diseases No disease was diagnosed.

Other Genotyping (Donor)
Is there genome-wide genotyping or functional data available?
Yes

Donor Relations
Other cell lines of this donor

External Databases (Donor)
BioSamples SAMEA2398402
HipSci HPSI-kolf

Ethics

Also have a look at the ethics information for the parental line WTSIi018-B .
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General
The source cell information can be found in the parental cell line WTSIi018-B.

Reprogramming method
Vector type Non-integrating
Vector Sendai virus

Vector free reprogramming

Other
Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Other medium:
Base medium: StemFlex™ Basal Medium
Main protein source:
Serum concentration: %

Characterisation

No characterisation data could be found for this subclone. Please open parental cell line WTSIi018-B .

Genotyping

Karyotyping (Cell Line)

Other Genotyping (Cell Line)

Genetic Modification

Disease/phenotype related modifications
Ataxia Telangiectasia Syndrome
Synonyms
  • Ataxia Telangiectasia
  • Louis-Bar Syndrome
  • ataxia-telangiectasia
  • Ataxia Telangiectasia Syndrome
  • Ataxia-telangiectasia
  • Ataxia-Telangiectasia Syndrome
show more synonyms
Genetic modifications
ATM (target)
Isogenic modification
11q22.3
NM_000051.4(ATM):c.9046A>C (p.Lys3016Gln)
Homozygous
Homozygous point mutation A->C in exon 63 at K3016 in the ATM gene. Introduction of K3016Q. When DNA damage accurs Lysine 3016 of ATM get acetylated and therefore activates ATM kinase activity. Cell line was generated by using CRISPR/Cas-mediated Homology-directed Repair.
Mutated