Chronic Activation of Tubulin Tyrosination Improves Heart Function
Summary
This study provides the first proof of concept that chronic activation of tubulin tyrosination in HCM mice and in human EHTs improves heart function and holds promise for targeting the nonsarcomeric cytoskeleton in heart disease.
| Authors | Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L |
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| Journal | Circulation research |
| Publication Date | 2024 Oct 11;135(9):910-932 |
| PubMed | 39279670 |
| PubMed Central | PMC11465905 |
| DOI | 10.1161/circresaha.124.324387 |