Generation of a human iPSC line CIBi011-A from amniocytes of a healthy fetus

Summary

Human induced pluripotent stem cells (iPSC) resemble human embryonic stem cells with potential to differentiate into cells of all adult tissues. Nonetheless human iPSCs may have an epigenetic memory of their donor tissue origin, are easier to differentiate to those lineages, and their potential to other cell fates can be controlled. We generated a human iPSC line CIBi011-A from amniocytes of a healthy fetus. CIBi011-A serves as a useful source to investigate the epigenetic memory of iPSCs. As an iPSC line from a healthy donor, this line can also serve as a potential cell source from which to develop stem cell-based cell therapies. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Shi Y, Wu S, Yang B, Yu B, Yan Y, Yang J, Chu M, Hu X
Journal Stem cell research
Publication Date 2022 May 4;62:102801
PubMed 35609349
DOI 10.1016/j.scr.2022.102801

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