FINCBi004-A

General

Cell Line

hPSCreg name FINCBi004-A
Cite as:
FINCBi004-A (RRID:CVCL_C9D7)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines No similar lines found.
Last update 23rd May 2023
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Provider

Generator Fondazione IRCCS Istituto Neurologico C. Besta (FINCB)
Owner Fondazione IRCCS Istituto Neurologico C. Besta (FINCB)
Distributors
Derivation country Italy

External Databases

BioSamples SAMEA113537083
Cellosaurus CVCL_C9D7
Wikidata Q123031278

General Information

Publications
* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • C19orf12 neurodegeneration with brain iron accumulation
  • MPAN
  • NBIA due to C19orf12 mutation
  • NBIA4
  • mitochondrial Protein-associated neurodegeneration
  • neurodegeneration with brain iron accumulation 4
  • neurodegeneration with brain iron accumulation caused by mutation in C19orf12
  • neurodegeneration with brain iron accumulation due to C19orf12 mutation
  • neurodegeneration with brain iron accumulation type 4
  • mitochondrial membrane protein-associated neurodegeneration
show more synonyms
Disease associated phenotypes
  • Movement disorder

Karyotyping (Donor)

Has the donor karyotype been analysed?
Unknown

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

External Databases (Donor)

BioSamples SAMEA113537170

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Please provide contact information of the holder of the original Donor Information Sheet. Dr. Giovanna Zorzi, Fondazione IRCCS Istituto Neurologico Carlo Besta
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Has the donor agreed to be re-contacted? Unknown
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? No information
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Ethikkommission der Technischen Universität München
Approval number 2022-674-S-SR
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
Synonyms
  • fibroblast
  • Fibroblasts
  • Fibroblast
  • FIBROBLAST
show more synonyms
Source cell origin

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Is reprogramming vector detectable?
No
Methods used
PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Matrigel/Geltrex
Feeder cells
No
Medium Essential 8™ Flex

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
Marker Expressed
SOX17
Yes
Mesoderm
Ont Id: UBERON_0000926
Marker Expressed
MESP1
Yes
Ectoderm
Ont Id: UBERON_0000924
Marker Expressed
PAX6
Yes

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XX
Karyotyping method: G-Banding

Other Genotyping (Cell Line)