Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration
Summary
This first patient-derived neuronal model of MPAN provides a useful tool for further research aimed at unraveling the complexities of this disease and developing potential therapeutic interventions. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
| Authors | Heger LM, Kertess L, Kaufhold C, Gubinelli F, Cardona-Alberich A, Özata G, Müller SA, Tschirner SK, Stehling O, Schifferer M, Peron C, Tiranti V, Lill R, Iuso A, Zecca L, Strupp M, Oertel W, Lichtenthaler SF, Burbulla LF |
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| Journal | Movement disorders : official journal of the Movement Disorder Society |
| Publication Date | 2025 Dec;40(12):2811-2818 |
| PubMed | 40948186 |
| PubMed Central | PMC12710160 |
| DOI | 10.1002/mds.70029 |