Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis


Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain limited for people with primary progressive MS (PPMS). PPMS accounts for ∼15% of MS diagnoses. Herein, we generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS cell types. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Mehta A, Lu P, Taylor BV, Charlesworth J, Cook AL, Burdon KP, Hewitt AW, Young KM
Journal Stem cell research
Publication Date 2021 Oct 12;57:102568
PubMed 34678664
DOI 10.1016/j.scr.2021.102568

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