Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson's disease patient with RAB39B gene mutation
Parkinson's disease is a common neurogenetic degenerative disease that can be caused by a variety of genetic mutations. RAB39B gene mutations have recently been identified as a cause of Parkinson's disease. We collected skin tissue samples from a family with mutations in RAB39B for our clinical study. Additionally, we constructed patient-derived induced pluripotent stem cells (iPSCs) from the patient's uncle using an unintegrated reprogramming plasmid transfection method to create a reliable cell model for the subsequent study of Parkinson's disease. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Sun H, Wang Z, Zhang Q, Liu Y, Yang J, Liu H, Shi C, Wang Y, Xu Y|
|Journal||Stem cell research|
|Publication Date||2021 Aug;55:102454|