Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson's disease patient carrying VPS13C and TBP mutations
Summary
Parkinson's Disease (PD), a prevalent neurodegenerative condition, is distinguished by its motor dysfunction. Induced pluripotent stem cells (iPSCs), derived from PD patients, constitute an exquisite investigative tool for elucidating the pathophysiology of the disease, assessing candidate therapeutics, and probing the potential for regenerative medicine approaches. The present study was designed to establish an iPSC line, designated TUSMi013-A, from the dermal fibroblasts of a 66-year-old female afflicted with PD, harboring mutations in VPS13C and TBP. This iPSC line offers a significant resource for the dissection of PD etiology and the innovation of novel therapeutic strategies. Copyright © 2024. Published by Elsevier B.V.
| Authors | Cui C, Chen J, Shen H, Zhang B |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Dec 18;83:103631 |
| PubMed | 39914017 |
| DOI | 10.1016/j.scr.2024.103631 |