Generation of ZZUi008-A, a transgene-free, induced pluripotent stem cell line derived from chorionic villi cells of a fetus with Duchenne muscular dystrophy


Duchenne muscular dystrophy (DMD) is a common X-linked recessive disorder for which there is no present cure. In this paper, we reported the generation of ZZUi008-A, an induced pluripotent stem cell(iPSC) line derived from chorionic villus(CV) cells of a fetus with a deletion mutation in exon 33 of the dystrophin gene (DMD). The cell line was generated using feeder-free and virus-free conditions, and the established cell line retains the original DMD mutation, a normal karyotype, expresses pluripotency markers, able to differentiate into three lineages. This ZZUi008-A cell line could provide a promising tool to study this complex disease. Copyright © 2018. Published by Elsevier B.V.

Authors Zhu X, Cai A, Meng J, Liu L, Cui S, Qu S, Zhao J, Liu N, Kong X
Journal Stem cell research
Publication Date 2018 Oct;32:47-50
PubMed 30172907
DOI 10.1016/j.scr.2018.07.017

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