Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome
Summary
Edwards' syndrome (trisomy 18) is a genetic disorder characterized by the presence of an extra chromosome 18. A specific induced pluripotent stem cell (iPSC) line, named BAFYi001-A, was generated from the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) of a patient with Edwards syndrome using an integration-free Sendai virus method. This line expresses markers for identifying undifferentiated hiPSCs, trilineage differentiation potential, and genetic fidelity in the context of trisomy 18. Therefore, this cell line serves as a reliable in vitro model for investigating the pathogenesis of Edward syndrome. Copyright © 2025. Published by Elsevier B.V.
| Authors | Yang Q, Liu S, Ruan J, Sun B, Chen X, Lai X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 May 13;86:103735 |
| PubMed | 40375407 |
| DOI | 10.1016/j.scr.2025.103735 |