Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease
Summary
This study is the first proof-of-concept that human microglial can be modulated using ASOs in a dose-dependent manner to manipulate microglia phenotypes and response to neurodegeneration in vivo. © 2024. The Author(s).
| Authors | Vandermeulen L, Geric I, Fumagalli L, Kreir M, Lu A, Nonneman A, Premereur J, Wolfs L, Policarpo R, Fattorelli N, De Bondt A, Van Den Wyngaert I, Asselbergh B, Fiers M, De Strooper B, d'Ydewalle C, Mancuso R |
|---|---|
| Journal | Molecular neurodegeneration |
| Publication Date | 2024 Apr 24;19(1):37 |
| PubMed | 38654375 |
| PubMed Central | PMC11040766 |
| DOI | 10.1186/s13024-024-00725-9 |