Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells


The expression of LIF and its receptors is low in undifferentiated hESCs but increases during differentiation. Added LIF does not prevent spontaneous differentiation. Suppressor of cytokine signaling-1 may prevent LIF signaling in hESCs.

Authors Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O
Journal Fertility and sterility
Publication Date 2006 Oct;86(4 Suppl):1193-209
PubMed 16949591
DOI 10.1016/j.fertnstert.2005.12.081

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