Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells
Summary
The expression of LIF and its receptors is low in undifferentiated hESCs but increases during differentiation. Added LIF does not prevent spontaneous differentiation. Suppressor of cytokine signaling-1 may prevent LIF signaling in hESCs.
| Authors | Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O |
|---|---|
| Journal | Fertility and sterility |
| Publication Date | 2006 Oct;86(4 Suppl):1193-209 |
| PubMed | 16949591 |
| DOI | 10.1016/j.fertnstert.2005.12.081 |