Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease


MEOX2 mutation has been reported as a potential cause of familial Alzheimer's disease. Recently, a novel MEOX2 mutation was identified in a family with Alzheimer's disease. The dermal fibroblasts of the patient were obtained and successfully transformed into induced pluripotent stem cells (iPSCs), employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC. Our model may offer a good platform for further research on the pathomechanism, drug testing, and gene therapy of this disease. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang Y, Sun H, Yang J, Shi C, Liu Y, Xu Y, Zhang J
Journal Stem cell research
Publication Date 2019 Jan;34:101366
PubMed 30616143
DOI 10.1016/j.scr.2018.101366

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