Establishment of an induced pluripotent stem cell line SPHi001-A from a systemic lupus erythematosus patient combined with preeclampsia and psoriasis


Systemic lupus erythematosus (SLE) is a heterogeneous, autoimmune disease that can affect multiple organs and systems such as skin, joints, kidneys, hematologic system or central nervous system. Women of childbearing age are the predominate population affected by SLE. In this study, we generated an iPS cell line from a 30-year-old female who was pregnant with a gestational age of 27 weeks and diagnosed with severe preeclampsia, SLE and psoriasis. This patient-specific iPSC line will be useful to create the specific disease model of systemic lupus erythematosus to elucidate the pathological mechanisms and develop drug screening. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Li D, Hong X, Li W, Meng S, Yu H, Zhang X, Wang C, Samokhvalov IM, Liu D, Tang D, Dai Y
Journal Stem cell research
Publication Date 2021 Mar;51:102192
PubMed 33516123
DOI 10.1016/j.scr.2021.102192

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