Generation of refractory schizophrenia patient-derived induced pluripotent stem cell line UJSi001-A


Schizophrenia is considered one of the most serious mental disorders nowadays. Approximately 30-60% of people with schizophrenia do not present adequate response to drug treatment and persist with symptoms of the disease; they are known as refractory schizophrenic people. We generated induced pluripotent stem cells (iPSCs) from a refractory schizophrenia patient by electroporation of peripheral blood mononuclear cells (PBMC) with episomal plasmids encoding OCT 4, SOX 2, NANOG, LIN 28, KLF 4 and LMYC. The resulting iPSCs had normal karyotype, were free of genomically integrated episomal plasmids, expressed pluripotency markers, and could differentiate into the three germ layers in vivo. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Sun J, Zhang X, Cong Q, Wang C, Chen D, Wang Y, Wang X, Yi Z, Qin S
Journal Stem cell research
Publication Date 2019 Jul;38:101460
PubMed 31102833
DOI 10.1016/j.scr.2019.101460

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