UBCi001-A

Registration Summary:

A P E C

GRN-R418X, R418X+/-

The cell line is not submitted yet.

(only basic data is shown)

General

iPSC Line
hPSCreg name	UBCi001-A
Cite as:	UBCi001-A (RRID:CVCL_YC92)
Alternative name(s)	GRN-R418X, R418X+/-
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	No similar lines found.
Last update	24th May 2022
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Provider
Generator	University of British Columbia (UBC) Contact: University of British Columbia (UBC)
Owner	University of British Columbia (UBC)
Distributors	University of British Columbia (UBC)
External iPSC Databases
Cellosaurus	CVCL_YC92
Wikidata	Q98133805
General iPSC Information
Publications	Frew J et al. Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation. Stem cell research. 2019 Dec;41:101582. Frew J et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Molecular neurodegeneration. 2020 Mar 16;15(1):21. Gaweda-Walerych Katarzyna et al. Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells. Translational Neurodegeneration. 2025-04-16.
* Is the cell line readily obtainable for third parties?	No

iPSC Derivation

General