Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress
Summary
Together, these data suggest that the apoptotic response was properly restored during reprogramming with mRNA, and that apoptosis is an important mechanism shared by hiPS and hES cells to maintain their genomic integrity when a replication stress occurs.
| Authors | Desmarais JA, Unger C, Damjanov I, Meuth M, Andrews P |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2016 Jan 25;7:17 |
| PubMed | 26810087 |
| PubMed Central | PMC4727355 |
| DOI | 10.1186/s13287-016-0279-2 |