Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress


Together, these data suggest that the apoptotic response was properly restored during reprogramming with mRNA, and that apoptosis is an important mechanism shared by hiPS and hES cells to maintain their genomic integrity when a replication stress occurs.

Authors Desmarais JA, Unger C, Damjanov I, Meuth M, Andrews P
Journal Stem cell research & therapy
Publication Date 2016 Jan 25;7:17
PubMed 26810087
PubMed Central PMC4727355
DOI 10.1186/s13287-016-0279-2

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