Generation and characterization of iPSCs from a patient with obsessive-compulsive disorder, his mother with schizophrenia and his healthy father


Schizophrenia (SCZ) and obsessive-compulsive disorder (OCD) are complex polygenic disorders with brain morphology abnormalities. The etiologies and relationship of both disorders remain elusive, and should be further investigated. Thus, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) from an OCD patient, his mother with SCZ and his healthy father with reprograming method. All iPSCs were characterized to have normal karyotype and expression of pluripotency makers. These iPSCs will be a valuable model to elucidate the pathophysiological mechanisms and association of both diseases. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Yuan Yin X, Hua Zhu Z, Feng Chen R, Li J, Ya Zhang G, Long Hou W, Nan Zhuang N, Cai Y, Bin Dai N, Liu F, Wang J, Fang Jia Q, Hui L
Journal Stem cell research
Publication Date 2023 Feb;66:102993
PubMed 36502622
DOI 10.1016/j.scr.2022.102993

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