Generation of a human induced pluripotent stem cell line (JSPHi003-A) from a patient with atrial fibrillation and ventricular tachycardia carrying LMNA frame shift mutation (c.1304_1307dup)
The iPSC line was generated from the peripheral blood mononuclear cells (PBMCs) from a 53-year-old female patient carrying the LMNA gene mutation (c.1304_1307dup) diagnosed with atrial fibrillation and paroxysmal ventricular tachycardia. Through comprehensive detection, it was verified that the cell line had the LMNA gene mutation, normal karyotype, and the potential to differentiate into the three germ layers. This cell line may reveal potential therapeutic targets for atrial and ventricular arrhythmias caused by LMNA mutations. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Lin Z, Cheng H, Zhang Y, Zheng B, Zhang F, Lin Y, Zhu Y, Ju W, Cui C, Chen M|
|Journal||Stem cell research|
|Publication Date||2022 Sep 7;64:102909|