Generation of human induced pluripotent stem cell lines from patients with selective IgA deficiency


Selective immunoglobulin-A deficiency (IgAD) is the most common primary immunodeficiency (PID) in the Western world and results in higher susceptibility to infections, autoimmune disorders and malignancies. We generated human induced pluripotent stem cell lines from two patients with selective IgAD, PHAi001 and PHAi002. Patient samples were reprogrammed using non-integrative based methods. Pluripotency of the PHAi001 and PHAi002 cell lines was confirmed by their expression of stem cell markers and capacity to differentiate into cells of the three germ layers. The PHAi001 and PHAi002 lines are a unique resource for experimental modeling of selective IgAD and associated disorders. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Arias-Fuenzalida J, Yu J, Du L, Custodio J, Notarangelo LD, Hammarström L, Pan-Hammarström Q
Journal Stem cell research
Publication Date 2019 Dec;41:101613
PubMed 31689593
DOI 10.1016/j.scr.2019.101613

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