Generation of two human iPSC lines (UUIGPi013-A and UUIPGi014-A) from cases with Down syndrome and full trisomy for chromosome 21 (T21)


Down syndrome (DS) is caused by trisomy for chromosome 21 (T21). We generated two induced pluripotent stem cell (iPSC) lines from skin fibroblasts of two males with DS using Sendai virus delivery of OCT4, SOX2, KLF4, and c-MYC. Characterization of the two iPSC lines, UUIGPi013-A and UUIPGi014-A, showed that they are genetically stable with a 47,XY,+21 karyotype. Both lines displayed expression of pluripotency markers and trilineage differentiation capacity. These two iPSC lines provide a useful resource for DS modeling and pharmacological interventions. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Schuster J, Hoeber J, Sobol M, Fatima A, Annerén G, Dahl N
Journal Stem cell research
Publication Date 2020 Dec;49:102081
PubMed 33220594
DOI 10.1016/j.scr.2020.102081

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