Production and validation of human induced pluripotent stem cell line from sporadic amyotrophic lateral sclerosis (SALS)


Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the loss of upper motor neurons in the cortex and lower motor neurons in the brain stem and spinal cord regressively. The vast majority of ALS cases have no familial history are apparently sporadic (SALS), making the modeling of SALS essential to the development of ALS therapeutics. Therefore, human induced pluripotent stem cell (iPSC) from peripheral blood mononuclear cells of a 64-year-old SALS patient were produced using a virus-free protocol and characterized using standard validate methods. This generated iPSC line could be useful to reveal SALS mechanisms and screen drug development. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Ma J, Feng B, Kong D, He J, Guo R, Amponsah AE, Zhang W, Zhang S, Lv F, Song Y, Liu A, Cui H
Journal Stem cell research
Publication Date 2020 Apr;44:101760
PubMed 32203916
DOI 10.1016/j.scr.2020.101760

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