Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia carrying variants of -28A > G and IVS-II-654C > T in HBB

Summary

β-thalassemia is mostly caused by homozygous or compound heterozygous variants in HBB. We generated a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia major, carrying compound heterozygous -28A > G and IVS-II-654C > T variants in HBB gene. This line will be a valuable resource for disease modeling and testing gene therapies for β-thalassemia. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Wu S, Wei H, Chu M, Weng Z
Journal Stem cell research
Publication Date 2020 Oct 29;49:102074
PubMed 33157391
DOI 10.1016/j.scr.2020.102074

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