Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia carrying variants of -28A > G and IVS-II-654C > T in HBB
Summary
β-thalassemia is mostly caused by homozygous or compound heterozygous variants in HBB. We generated a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia major, carrying compound heterozygous -28A > G and IVS-II-654C > T variants in HBB gene. This line will be a valuable resource for disease modeling and testing gene therapies for β-thalassemia. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wu S, Wei H, Chu M, Weng Z |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Dec;49:102074 |
| PubMed | 33157391 |
| DOI | 10.1016/j.scr.2020.102074 |