Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues
Summary
Our 'omics data document the involvement of inflammation, energy metabolism, and extracellular vesicle homeostasis. This demonstrates the potential to identify biological signatures from peripheral tissues in HD suitable as biomarkers in clinical trials. The generated data, complemented by the primary cell lines established from peripheral tissues, and a large panel of iPSC lines that can serve as human models of HD are a valuable and unique resource to advance the current understanding of molecular mechanisms driving HD pathogenesis. © 2022. The Author(s).
| Authors | Neueder A, Kojer K, Hering T, Lavery DJ, Chen J, Birth N, Hallitsch J, Trautmann S, Parker J, Flower M, Sethi H, Haider S, Lee JM, Tabrizi SJ, Orth M |
|---|---|
| Journal | Genome biology |
| Publication Date | 2022 Sep 7;23(1):189 |
| PubMed | 36071529 |
| PubMed Central | PMC9450392 |
| DOI | 10.1186/s13059-022-02752-5 |
Research Projects
Cell Lines
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