Generation of an induced pluripotent stem cell line from chorionic villi of a Patau syndrome spontaneous abortion


Patau syndrome is a rare congenital malformation syndrome due to the presence of an extra chromosome 13. In this paper, we report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Patau syndrome. The Patau syndrome villus induced pluripotent stem cell line retains the original trisomy 13 karyotype, expresses pluripotency markers and induces teratoma formation in NOD-SCID mice. This pluripotent stem cell model of Patau syndrome should serve as a tool to study this congenital malformation syndrome. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Long P, Liu Z, Wu B, Chen J, Sun C, Wang F, Huang Y, Chen H, Li Q, Ma Y
Journal Stem cell research
Publication Date 2020 May;45:101789
PubMed 32361311
DOI 10.1016/j.scr.2020.101789

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