Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system

Summary

In conjunction, our results described a simple serum-free platform to differentiate human the iPSCs into hematopoietic progenitor cells. This platform is an emerging application of iPSCs in vitro disease modeling, which can significantly improve the search for new pharmacological drugs for sickle cell disease. Copyright © 2020 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.

Authors Paes BCMF, Stabeli LCJR, Costa PNM, Orellana MD, Kashima S, Covas DT, Picanço-Castro V
Journal Hematology, transfusion and cell therapy
Publication Date 2021 Apr-Jun;43(2):156-164
PubMed 32229108
PubMed Central PMC8211631
DOI 10.1016/j.htct.2020.01.005

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