Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system
Summary
In conjunction, our results described a simple serum-free platform to differentiate human the iPSCs into hematopoietic progenitor cells. This platform is an emerging application of iPSCs in vitro disease modeling, which can significantly improve the search for new pharmacological drugs for sickle cell disease. Copyright © 2020 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.
| Authors | Paes BCMF, Stabeli LCJR, Costa PNM, Orellana MD, Kashima S, Covas DT, Picanço-Castro V |
|---|---|
| Journal | Hematology, transfusion and cell therapy |
| Publication Date | 2021 Apr-Jun;43(2):156-164 |
| PubMed | 32229108 |
| PubMed Central | PMC8211631 |
| DOI | 10.1016/j.htct.2020.01.005 |