An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility
Summary
The results suggest an important role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress, which could make it an interesting target for cardiac therapy.
| Authors | Madsen A, Höppner G, Krause J, Hirt MN, Laufer SD, Schweizer M, Tan WLW, Mosqueira D, Anene-Nzelu CG, Lim I, Foo RSY, Hansen A, Eschenhagen T, Stenzig J |
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| Journal | Circulation |
| Publication Date | 2020 Oct 20;142(16):1562-1578 |
| PubMed | 32885664 |
| PubMed Central | PMC7566310 |
| DOI | 10.1161/circulationaha.119.044444 |