Generation of human induced pluripotent stem cells (SDUKIi002-A) from a 22-year-old male diagnosed with autism spectrum disorder


Autism spectrum disorders are characterized by impaired social interaction and communication as well as restricted and repetitive interests and behavior. Increasing evidence points to an early-stage disruption of brain development. A human-induced pluripotent stem cell line (SDUKIi002-A) was created from skin fibroblasts from a 22-year old autistic male identified in the "FYNEN-cohort" of Southern Denmark. Reprogramming of the fibroblasts was performed using integration-free episomal plasmids. Further characterization confirmed the expression of pluripotency markers, differentiation into the three germ layers, absence of chromosomal abnormalities, and mycoplasma infection. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Kamand M, Ilieva M, Forsberg SL, Thomassen M, Fex Svenningsen Å, Holst B, Meyer M, Michel TM
Journal Stem cell research
Publication Date 2020 Jul;46:101834
PubMed 32447258
DOI 10.1016/j.scr.2020.101834

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