Generation and characterization of iPS cell line (CTGUi001-A) from skin fibroblasts of a patient with Fabry disease
Summary
We have generated an iPSCs line (CTGUi001-A) from dermal fibroblasts of a 16-year-old male Fabry disease patient with a novel GLA gene mutation (c.156C > A) using Sendai virus encoding the four Yamanaka factors OCT4, SOX2, KLF4, and c-MYC. The CTGUi001-A iPSC line displayed typical embryonic stem cell-like morphology, carried the GLA gene mutation, expressed several pluripotent stem cell makers, retained normal karyotype (46, XY) and was capable of forming teratomas containing three germ layers. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Qin Y, Zhan JQ, Ma CJ, Cao CY, Zhang Y, Min YT, Lv YF |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Jun;69:103063 |
| PubMed | 36917862 |
| DOI | 10.1016/j.scr.2023.103063 |