UCLi017-A

Registration Summary:

A P E C

WT2

The cell line is not submitted yet.

(only basic data is shown)

General

iPSC Line
hPSCreg name	UCLi017-A
Cite as:	UCLi017-A (RRID:CVCL_A4DL)
Alternative name(s)	WT2
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	No similar lines found.
Last update	27th April 2020
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Provider
Generator	University College London (UCL)
External iPSC Databases
Cellosaurus	CVCL_A4DL
Wikidata	Q105511326
General iPSC Information
Publications	Méjécase C et al. Generation of two human control iPS cell lines (UCLi016-A and UCLi017-A) from healthy donors with no known ocular conditions. Stem cell research. 2020 Dec;49:102113. Lima Cunha D et al. hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers. International journal of molecular sciences. 2021 Feb 11;22(4). Eintracht J et al. Efficient embryoid-based method to improve generation of optic vesicles from human induced pluripotent stem cells. F1000Research. 2022;11:324. Owen N et al. Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina. The Journal of pathology. 2023 Apr;259(4):441-454. Lima Cunha D et al. Restoration of functional PAX6 in aniridia patient iPSC-derived ocular tissue models using repurposed nonsense suppression drugs. Molecular therapy. Nucleic acids. 2023 Sep 12;33:240-253. Eintracht Jonathan et al. Disruption of common ocular developmental pathways in patient-derived optic vesicle models of microphthalmia. Stem Cell Reports. 2024-06-00. Romero-Vázquez S et al. Generation of a human iPSC line (UCLi025-A) from a patient with PHARC syndrome harbouring biallelic variants in ABHD12. Stem cell research. 2025 Mar;83:103661. Méjécase Cécile et al. Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and implicates cone involvement in retinal organoids. Frontiers in Cell and Developmental Biology. 2025-04-29. Harding Philippa et al. Variant-specific disruption to notch signalling in PAX6 microphthalmia and aniridia patient-derived hiPSC optic cup-like organoids. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2025-08-00.

iPSC Derivation

General