Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A)


The induced pluripotent stem cell (iPSC) technology has offered an unprecedented opportunity for disease modelling and drug discovery. Here we used non-integrating Sendai viral method and derived iPSCs from three young healthy Caucasian donors. All iPSCs expressed pluripotency markers highly and could be differentiated into three germ lineages. They possess normal karyotype which was confirmed by whole genome SNP array. The availability of the healthy control iPSCs offers an opportunity for phenotypic comparison and genome editing for a variety of diseases. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Ding Y, de la Cruz BM, McInerney V, Lu Y, Yang G, Qian X, Li W, Krawczyk J, Howard L, O'Brien T, Gallagher L, Shen S
Journal Stem cell research
Publication Date 2020 Dec;49:102101
PubMed 33370872
DOI 10.1016/j.scr.2020.102101

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