hPSCreg®
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MICCNi002-A

Registration Summary:

ADHD Stem Cell Study_subject 5, clone A1, hiPSC_03 affected sibling

MICCNi002-A

General

Cell Line
hPSCreg Name
MICCNi002-A
Alternative name(s)
ADHD Stem Cell Study_subject 5, clone A1, hiPSC_03 affected sibling
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
Last update 26th January 2021
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Provider
Generator ​Monash Institute of Cognitive and Clinical Neurosciences (MICCN)

External Databases
Cellosaurus CVCL_UM15
CLO CLO_0102299
BioSamples SAMEA8093239
Wikidata Q95989695

General Information
Publications
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information
Sex male
Ethnicity Caucasian

Phenotype and Disease related information (Donor)
Diseases A disease was diagnosed.
attention deficit hyperactivity disorder
attention deficit hyperactivity disorder in the OLS
Synonyms
  • ADHD
  • Syndromes, Hyperkinetic
  • Attention Deficit Hyperactivity Disorders
  • Attention Deficit Disorder with Hyperactivity
  • ATTENTION DEFICIT HYPERACTIVITY DIS
  • Brain Dysfunction, Minimal
  • Minimal Brain Dysfunction
  • Deficit Disorders, Attention
  • Attention Deficit Disorders with Hyperactivity
  • Deficit Disorder, Attention
  • ATTENTION DEFICIT DIS
  • Hyperkinetic Syndrome
  • Attention Deficit Disorders
  • Disorder, Attention Deficit
  • Disorders, Attention Deficit
  • ADDH
  • ATTENTION DEFICIT DIS WITH HYPERACTIVITY
  • Dysfunction, Minimal Brain
  • attention deficit-hyperactivity disorder
  • attention deficit/hyperactivity disorder
  • attention deficit-hyperactivity disorder, susceptibility to
  • attention deficit hyperactivity disorder
  • Attention Deficit Disorder
show more synonyms

Karyotyping (Donor)
Has the donor karyotype been analysed?
Yes
46,XY
Karyotyping method: G-Banding

Donor Relations
Other cell lines of this donor

External Databases (Donor)
BioSamples SAMEA4984142

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? No
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent expressly prevent the derivation of pluripotent stem cells? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? Yes
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Monash University Human Research Ethics Committee
Approval number CF15/2566 - 2015001048
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? No
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General
Source cell type
peripheral blood mononuclear cell
peripheral blood mononuclear cell in the OLS
A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.
Source cell origin
blood
blood in the OLS
A fluid that is composed of blood plasma and erythrocytes.
Synonyms
  • portion of blood
  • vertebrate blood

Reprogramming method
Vector type Non-integrating
Vector Sendai virus
Genes
Is reprogramming vector detectable?
No
Methods used
RT-PCR

Vector free reprogramming

Other
Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR FACS Enzymatic Assay Expression Profiles
TRA 1-60
Yes
NANOG
Yes
Klf4
Yes
POU5F1 (OCT-4)
Yes
Self-renewal
Unknown
Endoderm
Unknown
Mesoderm
Unknown
Ectoderm score
Positive

Genotyping

Karyotyping (Cell Line)
Has the cell line karyotype been analysed?
Yes
46,XY
Karyotyping method: G-Banding

Other Genotyping (Cell Line)