Generation of a human iPSC line, INMi005-A, from a patient with non-syndromic USH2A-associated retinitis pigmentosa
Summary
We report here the generation of the human iPSC line INMi005-A from a patient with non-syndromic autosomal recessive retinitis pigmentosa caused by compound heterozygous mutations in the USH2A gene. The reprogramming of primary human dermal fibroblasts was performed using the non-integrative Sendai virus method and the OSKM transcription factor cocktail. The generated INMi005-A iPSC line is pluripotent and genetically stable, and will represent a valuable tool for understanding the pathophysiology associated with USH2A mutations. Copyright © 2022. Published by Elsevier B.V.
| Authors | Sanjurjo-Soriano C, Erkilic N, Vache C, Dubois G, Roux AF, Meunier I, Kalatzis V |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Apr;60:102738 |
| PubMed | 35248879 |
| DOI | 10.1016/j.scr.2022.102738 |