Generation of integration-free induced pluripotent stem cell lines from four pediatric ADHD patients
Summary
Human induced pluripotent stem cell (iPSC) lines have been derived from four male patients with childhood attention-deficit hyperactivity disorder (ADHD). Children and adolescents between the ages 6 and 18 suffering from ADHD were recruited for this work. Isolated keratinocytes or peripheral blood mononuclear cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Grossmann L, Yde Ohki CM, Döring C, Hoffmann P, Herms S, Werling AM, Walitza S, Grünblatt E |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 May;53:102268 |
| PubMed | 33662736 |
| DOI | 10.1016/j.scr.2021.102268 |