Generation of integration-free induced pluripotent stem cell lines from four pediatric ADHD patients


Human induced pluripotent stem cell (iPSC) lines have been derived from four male patients with childhood attention-deficit hyperactivity disorder (ADHD). Children and adolescents between the ages 6 and 18 suffering from ADHD were recruited for this work. Isolated keratinocytes or peripheral blood mononuclear cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Grossmann L, Yde Ohki CM, Döring C, Hoffmann P, Herms S, Werling AM, Walitza S, Grünblatt E
Journal Stem cell research
Publication Date 2021 May;53:102268
PubMed 33662736
DOI 10.1016/j.scr.2021.102268

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