Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson's disease with PARK2 mutation
Summary
PARK2 is the most common autosomal recessive form of Parkinson's disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem cell (iPSC) line from a patient harboring a homozygous exon 3 deletion in PARK2. The established iPSCs showed pluripotency, the capacity to differentiate into the three germ layers, and normal karyotypes. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Ishikawa KI, Okuzumi A, Yoshino H, Hattori N, Akamatsu W |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Apr;76:103323 |
| PubMed | 38309147 |
| DOI | 10.1016/j.scr.2024.103323 |