Generation of an iPSC line (ZZUNEUi021-A) from a hypertrophic cardiomyopathy patient with TNNT2 mutation


A 25-years-old hypertrophic cardiomyopathy male patient donated his peripheral blood mononuclear cells (PBMCs) with heterozygote mutation in theTNNT2 gene. We generated induced pluripotent stem cell (iPSC) with normal karyotypic and expressing NANOG, Lin28, GDF3 and DNMT3. The iPSC line has demonstrated pluripotency by differentiating into three germ layers in vitro. The ZZUNEUi021-A would serve as an in vitro model for loss of TNNT2 function. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Dong Y, Li X, Fu W, Tian X, Guo G, Peng Y, Zhai Y, Zhao J, Ding Z, Zhao X, Dong J
Journal Stem cell research
Publication Date 2022 Jan;58:102622
PubMed 34929444
DOI 10.1016/j.scr.2021.102622

Research Projects

Cell Lines