Generation of an iPSC line (ZZUNEUi021-A) from a hypertrophic cardiomyopathy patient with TNNT2 mutation
Summary
A 25-years-old hypertrophic cardiomyopathy male patient donated his peripheral blood mononuclear cells (PBMCs) with heterozygote mutation in theTNNT2 gene. We generated induced pluripotent stem cell (iPSC) with normal karyotypic and expressing NANOG, Lin28, GDF3 and DNMT3. The iPSC line has demonstrated pluripotency by differentiating into three germ layers in vitro. The ZZUNEUi021-A would serve as an in vitro model for loss of TNNT2 function. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Dong Y, Li X, Fu W, Tian X, Guo G, Peng Y, Zhai Y, Zhao J, Ding Z, Zhao X, Dong J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jan;58:102622 |
| PubMed | 34929444 |
| DOI | 10.1016/j.scr.2021.102622 |