Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson's disease carrying variants in PRKN and HTRA2
Summary
Variations in PRKN or HTRA2 are associated with Parkinson's disease. We generated a human induced pluripotent stem cell (iPSC) line CIBi007-A from a patient with young-onset Parkinson's disease (YOPD) who carried variants in PRKN and HTRA2. The generated iPSCs resembled human embryonic stem cells, expressed pluripotency markers, exhibited a normal karyotype, and could be differentiated into three germ layers in vitro. This line will be valuable for investigating disease mechanisms of YOPD and screening candidate drugs. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Yan Y, Wu S, Jiang L, Yang B, Chen X, Liu Y, Yu B, Fu J, Yu J, Ning H, Chu M, Yang J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Jul 3;47:101905 |
| PubMed | 32688332 |
| DOI | 10.1016/j.scr.2020.101905 |