Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism


ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Tsai MH, Chiu YT, Chan DZ, Wen CH, Syu SH, Lu HE, Huang CF, Lin YJ, Chang SL, Lo LW, Huang CY, Hu YF, Hsieh PCH, Chen SA
Journal Stem cell research
Publication Date 2021 Jul;54:102416
PubMed 34118567
DOI 10.1016/j.scr.2021.102416

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