Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis


Exploring such targets to modulate CF phenotype represents a valuable opportunity for development of anti-fibrotic therapies. Also, we demonstrate that hiPSC-CF is a suitable cell source for preclinical research, displaying significantly lower basal activation level relative to primary cells, while being able to elicit a convergent response upon stimuli. Copyright © 2022 Moita, Silva, Diniz, Serra, Hoet, Barbas and Simão.

Authors Moita MR, Silva MM, Diniz C, Serra M, Hoet RM, Barbas A, Simão D
Journal Frontiers in cardiovascular medicine
Publication Date 2022;9:1015473
PubMed 36531712
PubMed Central PMC9751336
DOI 10.3389/fcvm.2022.1015473

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