Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
Summary
Exploring such targets to modulate CF phenotype represents a valuable opportunity for development of anti-fibrotic therapies. Also, we demonstrate that hiPSC-CF is a suitable cell source for preclinical research, displaying significantly lower basal activation level relative to primary cells, while being able to elicit a convergent response upon stimuli. Copyright © 2022 Moita, Silva, Diniz, Serra, Hoet, Barbas and Simão.
| Authors | Moita MR, Silva MM, Diniz C, Serra M, Hoet RM, Barbas A, Simão D |
|---|---|
| Journal | Frontiers in cardiovascular medicine |
| Publication Date | 2022;9:1015473 |
| PubMed | 36531712 |
| PubMed Central | PMC9751336 |
| DOI | 10.3389/fcvm.2022.1015473 |