p.A46T CAV3 hiPSCs #2


Cell Line

hPSCreg name HIMRi003-A
Cite as:
Alternative name(s)
p.A46T CAV3 hiPSCs #2
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
(p.A46T CAV3 hiPSCs #1)
Donor diseases:
Last update 6th October 2023
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Generator Heimer Institute for Muscle Research (HIMR)
Owner Heimer Institute for Muscle Research (HIMR)
Derivation country Germany

External Databases

BioSamples SAMEA114267275
Cellosaurus CVCL_D0FA
Wikidata Q123031674

General Information

* Is the cell line readily obtainable for third parties?
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex female
Age of donor (at collection) 60-64
Ethnicity Caucasian

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
  • qualitative or quantitative defects of caveolin-3

External Databases (Donor)

BioSamples SAMEA114267275


Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Please provide contact information of the holder of the original Donor Information Sheet. Prof. Dr. med. Matthias Vorgerd
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Open Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Ruhr-University Bochum, Medical Faculty
Approval number 15-5401, 08/2015
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation


Source cell type
Dermal fibroblasts are the major cell type in dermis and are commonly accepted as terminally differentiated cells.
Age of donor (at collection) 60-64

Reprogramming method

Vector type Integrating
Vector Virus (Lentivirus)
Is the used vector excisable?
Absence of reprogramming vector(s)?
Reprogramming vectors silenced?

Vector free reprogramming


Derived under xeno-free conditions
Derived under GMP?
Available as clinical grade?

Culture Conditions

Surface coating Matrigel/Geltrex
Medium Other medium:
Base medium: DMEMF12
Main protein source: Albumine
Serum concentration: %
Has Rock inhibitor (Y27632) been used at passage previously with this cell line?
Has Rock inhibitor (Y27632) been used at cryo previously with this cell line?
Has Rock inhibitor (Y27632) been used at thaw previously with this cell line?


Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
Differentiation Potency
Ont Id: UBERON_0000925
In vitro directed differentiation
Ont Id: UBERON_0000926
In vitro directed differentiation
Ont Id: UBERON_0000924
In vitro directed differentiation


Karyotyping (Cell Line)

Has the cell line karyotype been analysed?

Other Genotyping (Cell Line)