Generation and characterization of an integration-free iPSC line SDUBMSi006-A from a patient with Alport syndrome caused by COL4A3 gene mutations


Alport syndrome (AS) is a hereditary kidney disease caused by mutations in COL4A3, COL4A4, or COL4A5 genes. Here we report the generation of an induced pluripotent stem cell line (iPSC) from an AS patient carrying compound heterozygote mutations (c.4243G > C and c.4216G > A) in COL4A3 gene using non-integrative reprogramming technology. The established iPSC line demonstrates hESC morphology, expresses pluripotency markers, has normal karyotype, and is capable of differentiating into all three germ layers in vitro. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Ma Y, Wang Z, Liu X, Sun W, Gong Y, Liu G, Sun G
Journal Stem cell research
Publication Date 2021 Apr;52:102237
PubMed 33601099
DOI 10.1016/j.scr.2021.102237

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