WAe009-A-50

Registration Summary:

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General

iPSC Line
hPSCreg name	WAe009-A-50
Cite as:	WAe009-A-50 (RRID:CVCL_A5EP)
iPSC line type	Human embryonic stem cell (hESC)
Similar iPSC lines	No similar lines found.
Last update	26th January 2021
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Provider
Generator	Capital Medical University (CMU)
External iPSC Databases
Cellosaurus	CVCL_A5EP
Wikidata	Q107117425
General iPSC Information
Publications	Dong T et al. The establishment of a homozygous SNTA1 knockout human embryonic stem cell line (WAe009-A-50) using the CRISPR/Cas9 system. Stem cell research. 2021 Mar;51:102196. Dong T et al. SNTA1-deficient human cardiomyocytes demonstrate hypertrophic phenotype and calcium handling disorder. Stem cell research & therapy. 2022 Jun 30;13(1):288. Jimenez-Tellez N et al. Generation of two iPSC lines from long QT syndrome patients carrying SNTA1 variants. Stem cell research. 2023 Feb;66:103003. Liu Zhichen et al. Effects of nonsynonymous single nucleotide polymorphisms of the KIAA1217, SNTA1 and LTBP1 genes on the growth traits of Ujumqin sheep. Frontiers in Veterinary Science. 2024-05-02. Zhuang Mengjie et al. SNTA1 inhibits the PI3K/AKT signaling pathway leading to increased mitochondrial dysfunction and arrhythmia caused by diacetylmorphine. Ecotoxicology and Environmental Safety. 2024-11-00. Dong Tao et al. SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity. Scientific Reports. 2025-08-20.
Subclone of	WAe009-A