Generation of a human embryonic stem cell line (WAe009-A-43) carrying a Long QT syndrome related mutation in KCNH2 gene
Summary
The hereditary Long QT syndrome (LQTS) is a life-threaten channelopathy of the heart characterized by prolonged QT intervals and predisposition to occur polymorphic ventricular tachyarrhythmias. LQTS type 2 is the second most prevalent type of LQTS and more than 200 putative disease-causing mutations have been identified for KCNH2. Herein, we have generated a human embryonic stem cell line (WAe009-A-43) carrying a LQTS related mutation in KCNH2 (WAe009-A-43). The WAe009-A-43 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Wu X, Zhao Y, Wang X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Oct;48:101976 |
| PubMed | 32911324 |
| DOI | 10.1016/j.scr.2020.101976 |