Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations


Dilated cardiomyopathy (DCM) is a common heart disease that can lead to heart failure and sudden cardiac death. Mutations in the TTN gene are the most frequent cause of DCM. Here, we generated two human induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of two DCM patients carrying c.94816C>T and c.104188A>G mutations in TTN, respectively. The two lines exhibited a normal morphology, full expression of pluripotency markers, a normal karyotype and the ability of trilineage differentiation. The two lines can serve as useful tools for drug screening and mechanism studies on DCM. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zhang TT, Zhao SR, Alamana C, Shen M, Parikh V, Wheeler MT, Wu JC
Journal Stem cell research
Publication Date 2022 Oct 13;65:102941
PubMed 36270069
DOI 10.1016/j.scr.2022.102941

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