ZIPi013-A

Cell Line

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External Databases

General Information

• Vögtle FN et al. Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood. American journal of human genetics. 2018 Apr 5;102(4):557-573.
• Tandon R et al. Generation of two human isogenic iPSC lines from fetal dermal fibroblasts. Stem cell research. 2018 Dec;33:120-124.
• Witt G et al. An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds. Cell biology and toxicology. 2021 Apr;37(2):229-243.
• Woo MS et al. Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. The Journal of experimental medicine. 2021 May 3;218(5).
• Krasemann S et al. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem cell reports. 2022 Feb 8;17(2):307-320.
• Rothammer N et al. G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis. Science advances. 2022 Aug 5;8(31):eabm5500.
• Haferkamp U et al. Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease. Fluids and barriers of the CNS. 2023 Oct 31;20(1):78.
• Haferkamp U et al. Generation of two isogenic human iPSC lines (ZIPi013-B-1, ZIPi013-B-2) carrying a CRISPR/Cas9-mediated deletion of TRPM4. Stem cell research. 2024 Dec;81:103609.
• Krieg K et al. Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs. Cell reports methods. 2025 Dec 15;5(12):101236.
• Hartmann C et al. Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease. Fluids and barriers of the CNS. 2026 Jan 22;23(1):11.

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