Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease
Summary
Cell type-dependent transcriptional effects on LOAD BCECs were identified. Our study suggests that different brain cell types of the NVU have unique roles in maintaining barrier integrity that vary under healthy and LOAD conditions. . © 2023. The Author(s).
| Authors | Haferkamp U, Hartmann C, Abid CL, Brachner A, Höchner A, Gerhartl A, Harwardt B, Leckzik S, Leu J, Metzger M, Nastainczyk-Wulf M, Neuhaus W, Oerter S, Pless O, Rujescu D, Jung M, Appelt-Menzel A |
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| Journal | Fluids and barriers of the CNS |
| Publication Date | 2023 Oct 31;20(1):78 |
| PubMed | 37907966 |
| PubMed Central | PMC10617216 |
| DOI | 10.1186/s12987-023-00471-y |