FDHPIi001-A

General

Cell Line

hPSCreg name FDHPIi001-A
Cite as:
FDHPIi001-A (RRID:CVCL_C6PZ)
Cell line type Human induced pluripotent stem cell (hiPSC)
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Last update 1st February 2023
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Provider

Generator (WITHDRAWN) Fudan University (FDHPI)

External Databases

BioSamples SAMEA111491449
Cellosaurus CVCL_C6PZ
Wikidata Q117704334

General Information

Publications
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Stage
early-onset
Synonyms
  • Ongoing loss of nerve cells
  • Neuro-degenerative disease
  • Neurodegenerative disease
  • Progressive neurodegenerative disorder
show more synonyms
Genetic variants
Xp11.23
(NM_001029896.2):c.344+5G>T
splicing variation
Heterozygous
this variant did not report previously
Family history no

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
normal karyotyping

External Databases (Donor)

BioSamples SAMEA111491450

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? Yes
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Nanjing medical ethics
Approval number Nanjing medical ethics approval (2019) NO 119
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Episomal
Genes
Is reprogramming vector detectable?
No
Methods used
RT-PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium mTeSR™ 1

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
POU5F1 (OCT-4)
Yes
NANOG
Yes
Marker Present Absent
mCpG
OCT4 X
Morphology pictures
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
In vivo teratoma
Morphology
内胚层-肠道上皮组织-100x-1.tif
intestinal epithelium 100X
Mesoderm
Ont Id: UBERON_0000926
In vitro spontaneous differentiation
Cartilage Element
Ont Id: UBERON_0007844
In vitro spontaneous differentiation
Morphology
Neuroepithelial Stem Cell
Ont Id: CL_0002259
Ectoderm
Ont Id: UBERON_0000924
In vitro spontaneous differentiation
Morphology

Microbiology / Virus Screening

HIV 1 Negative
Hepatitis B Negative
Hepatitis C Negative
Mycoplasma Negative

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46,XX
Karyotyping method: G-Banding

Other Genotyping (Cell Line)