The cell line is not validated yet.

General

Cell Line

hPSCreg Name
FDCHi007-A
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
AIBNi016-A
(SPG2-S376C1)
Donor diseases:
hereditary spastic paraplegia 56
ZJSHi001-A
(ZJSHi-KCNB1)
Donor's gene variants:
KCNB1
Donor diseases:
developmental and epileptic encephalopathy, 26
SCTCi011-A
(IPS18-00072)
Donor diseases:
age-related macular degeneration
UKKi034-A
(NP0079-A, NP0079-7B)
Donor's gene variants:
KCNQ1, KCNQ1
Donor diseases:
long QT syndrome 1
UKKi034-B
(NP0079-B, NP0079-15B)
Donor's gene variants:
KCNQ1, KCNQ1
Donor diseases:
long QT syndrome 1
UKKi034-C
(NP0079-C, NP0079-16H)
Donor's gene variants:
KCNQ1, KCNQ1
Donor diseases:
long QT syndrome 1
CMCi009-A
(CMC-BHD-001)
Donor's gene variants:
FLCN
Donor diseases:
Birt-Hogg-Dube Syndrome
SCTCi015-A
(IPS19-00051)
Donor diseases:
Age-Related Macular Degeneration
PFIZi023-A
(B217c8)
Donor's gene variants:
GPR56, GPR56
Donor diseases:
Bilateral Frontoparietal Polymicrogyria
SCVIi091-A
(SCVI2617)
Donor diseases:
transthyretin amyloidosis
CABi003-A
(DH05, AMDdh05-MiPS4F16)
Donor diseases:
Age-Related Macular Degeneration
USPi006-A
(DFNA58-ipsc-dup1-cl2)
Donor diseases:
autosomal dominant nonsyndromic deafness 58
USPi007-A
(DFNA58-ipsc-dup2-cl5)
Donor diseases:
autosomal dominant nonsyndromic deafness 58
KMUGMCi001-A
(KMUGMCi001ACVRL1)
Donor diseases:
Telangiectasia, Hereditary Hemorrhagic
KMUGMCi004-A
(KMUGMCi004APC, KN615)
Donor diseases:
familial adenomatous polyposis
PFIZi032-A
(B214c8)
Donor's gene variants:
TSC2
Donor diseases:
Tuberous Sclerosis
WCHi006-A
Donor diseases:
Schizophrenia
CMCi001-A
(CMC-KIN-hiPSC)
Donor diseases:
karyomegalic interstitial nephritis
PCIi026-A
(PC085)
Donor diseases:
Waardenburg syndrome
PFIZi025-A
(B220c16)
Donor's gene variants:
KCNC1
Donor diseases:
epilepsy
PCIi032-A
(PC087)
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Waardenburg Syndrome
KMUGMCi005-A
(KMUGMCi005TMC8, KN627)
Donor diseases:
Epidermodysplasia Verruciformis
SZGJMSi001-A
(ZLP-2)
Donor diseases:
Schizophrenia
NIHTVBi019-A
(HT852)
Donor diseases:
Leukodystrophy
IMAGINi022-A
(IMAGINE022)
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Waardenburg syndrome
WCHi003-A
Donor diseases:
Schizophrenia
PUFHi004-A
(TMEM163 c.227T>C p.(Leu76Pro) iPSC)
Donor's gene variants:
TMEM 163
Donor diseases:
Leukodystrophy
SHCDNi006-A
(SHCDN006)
Donor diseases:
epilepsy
PCIi025-A
(PC084)
Donor diseases:
Waardenburg syndrome
CUIMCi005-A
(BB#2, BB9068#2)
Donor diseases:
Stargardt Disease
FJMUUHi001-A
Donor's gene variants:
PARK7
Donor diseases:
Parkinson's disease 7
SCTCi014-A
(IPS17-00056)
Donor diseases:
Age-Related Macular Degeneration
LZUSHi001-A
(ips98)
Donor diseases:
Generalized Epilepsy
SCTCi012-A
(IPS19-00027)
Donor diseases:
age-related macular degeneration
SCTCi013-A
(IPS19-00053)
Donor diseases:
age-related macular degeneration
USFi001-A
(1CN1.5)
Donor diseases:
Friedreich Ataxia
Last update 14th February 2022
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Provider

Generator Children’s Hospital of Fudan University (FDCH)

External Databases

BioSamples SAMEA10886707
CLO CLO_0103564
Cellosaurus CVCL_B5IK
Wikidata Q110432803

General Information

Publications
* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
developmental and epileptic encephalopathy 31

Karyotyping (Donor)

Has the donor karyotype been analysed?
Unknown

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

External Databases (Donor)

BioSamples SAMEA10886708

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Provide contact information of the holder of the original Donor Information Sheet: yuanfengzhou@fudan.edu.cn
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Contact information / weblink yuanfengzhou@fudan.edu.cn
Alternatives to consent are available? No
Is there other documentation provided to the donor for consenting purposes? No
Confirm that consent was obtained by a qualified professional Yes
Has the donor agreed to be re-contacted? Unknown
Has the donor been informed about how her/his data will be protected? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent expressly prevent the derivation of pluripotent stem cells? No
Does consent pertain to a specific research project? Yes
Details on restriction to research project Drug screening
Does consent permit unforeseen future research, without further consent? No
Does the consent permit uses of donated embryo/tissue or derived cell line intended for clinical treatment or human applications? Yes
Does consent expressly prevent development of commercial products? Yes
Does consent expressly prevent financial gain from any use of the donated embryo/tissue, including any product made from it? Yes
Does consent expressly permit storage of donated embryo/tissue for an unlimited time? Yes
Does consent expressly permit storage of cells derived from the donated embryo/tissue for an unlimited time? Yes
Does consent prevent the DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No

Does consent permit research by

an academic institution? Yes
a public organisation? Yes
a non-profit company? Yes
a for-profit corporation? No
Does consent expressly permit collection of genetic information? Yes
Does consent expressly permit storage of genetic information? Yes
Does consent prevent dissemination of genetic information? Yes
Has the donor been informed that their donated biosample or derived cells may be tested for the presence of microbiological agents / pathogens? Yes
Has the donor consented to receive information discovered during use of donated embryo/tissue that has significant health implications for the donor? Yes
How may genetic information associated with the cell line be accessed? No information
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Does the consent anticipate that the donor will be notified of results or outcomes of any research involving the donated samples or derived cells? No
Does the consent permit the donor, upon withdrawal of consent, to stop the use of the derived cell line(s) that have already been created from donated samples? Yes
Does the consent permit the donor, upon withdrawal of consent, to stop delivery or use of information and data about the donor? Yes
Does consent permit access to medical records of the donor? No
Does consent permit access to any other source of information about the clinical treatment or health of the donor? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Children's Hospital of Fudan University
Approval number Approval no. 2021/75
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? No
Do you have obligations to third parties in regard to the use of the cell line? No
Are you aware of any further constraints on the use of the donated embryo/tissue or derived cells? No
Is there an MTA available for the cell line? No
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?
Are you aware of any constraints on the use or distribution of the cell line from the owner or any parties identified in the query above? No

hIPSC Derivation

General

Source cell type
Peripheral Blood Mononuclear Cell
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Episomal
Is reprogramming vector detectable?
Yes
Methods used
PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Matrigel/Geltrex
Medium mTeSR™ Plus

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR FACS Enzymatic Assay Expression Profiles

Microbiology / Virus Screening

Mycoplasma Negative

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Unknown

Other Genotyping (Cell Line)